Resurfacing work will start on the A158, between Church Lane and Gunby Roundabout, on Monday.
The road will be closed up to the roundabout from 8pm to 6am on weeknights, from 15 – 26 April. Gunby Lane junction will also be closed. Traffic will be diverted via the A158, A16, A1028 and vice versa.
Gunby Roundabout will be resurfaced at the same times between 22 and 26 April. Partial diversions will also be in place for this later work.
Roman Mastakov, project officer, said: “We will be working through the night when traffic is lighter to improve the surface on this road.”
Advance warning signs are in place.