Emergency services are dealing with a serious RTC on the A158 at the Horncastle side of Wragby.
The collision occurred shortly after 3pm this afternoon (Friday) and involves a single vehicle with four occupants.
One of the passengers is being taken to Hull Royal Infirmary by air ambulance and the driver has gone to Lincoln County Hospital. A third passenger is also thought to be seriously injured and a fourth is walking wounded.
Details of the injured are not yet confirmed.
The A158 may be closed for some time and motorists are asked to avoid the area and follow diversions.